学部紹介 Research:Tokyo University of Pharmacy and Life Sciences

Department of Molecular Biology

Our department studies life sciences at molecular level with experimental or theoretical approach in order to contribute to innovative development of life sciences including drug discovery and development.

Laboratory of Bioorganic Chemistry

We have been studying the following subjects regarding organic chemistry;

  • Development of an efficient synthetic route to complex natural products and biologically active compounds
  • Development of novel and useful synthetic methods for natural product synthesis
  • Development of functional fluorescence molecules.

Laboratory of Molecular Neuroscience and Neurology

  • Neural information processing mediated by network activities inhippocampal circuitry.
  • Study on dynamics of neural system underlying the behavior of Drosophila melanogaster.
  • Information processing mechanisms mediated by the neural networksinvolved in chemical senses.
  • Neural basis of olfaction and colorvision in Drosophila melanogaster.

Laboratory of Bioanalytical and Environmental Chemistry

The mission of our laboratory is to develop new analytical methods that can measure and/or observe directly interactions between chemical substances and living cells/organisms, and to understand molecular, cellular, individual and ecosystem-level mechanism that life respond to the chemical environmental changes. Our long-term goal is to use the knowledge gained from our research to contribute to solution of drug design or an environmental problem.

Laboratory of Bioinformatics

Main interest of our laboratory is what kind of principle governs the protein architecture and how it is related to molecular functions. We are investigating the following topics by physicochemical methods and bioinformatics:

  • Application of solution X-ray scattering to construct the protein structure
  • Structure-based drug design by computational modeling

Laboratory of Molecular and Chemical Biology

  • Molecular and chemical biology using C. elegans as a model organism; aging, behavioral control, and organ morphogenesis.
  • Searching for natural bioactive compounds from plants.
  • Redox biology using bioimaging techniques; development of fluorescent probes and analyses.

Laboratory of Computational Biophysics

We are interested in the investigation ofthe structure and dynamics of biomolecules and biological systems by computersimulation. Our current research topics include:

  • Molecular dynamics simulation of peptides and proteins related to cell attachment, protein fiber and diabetes
  • Numerical simulation of twitching motility of bacterium
  • Simulation of coarse-grained model of gel and polymers.

Laboratory of Cell Signaling

  • Regulation of membrane trafficking from the endoplasmic reticulum.
  • Molecular, biochemical, and physiological analysis of intracellular phospholipase A1 family proteins.
  • Professor
    Akihiro Ito
  • Assistant professor
    Yuki Maemoto

Laboratory of Language Sciences Laboratory

Language is a system, ability, a communication tool, and something that is common to all human beings. We are committed to study language (a language or languages), focusing on the following subfields of linguistics: socio- linguistics, pragmatics, corpus analyses, and second language acquisition.

Laboratory of Teacher Certification program

The purpose is to provide students with knowledge and experience related to theories and practice of school science education.

  • the awareness of pedagogy:fundamental theories of pedagogy
  • education processes and instruction methods
  • student instruction,education consultation and career guidance.

Department of Applied Life Science

Our department studies biotechnology, microbiology and plant science for contributing to sustainable developments, environmental protection, renewable energy, and food production.

Laboratory of Bioengineering

Laboratory of Food Science and Technology

Laboratory of Environmental Molecular Physiology

We have been engaged in the study of stress-induced molecular responses at systemic and cellular levels. Especially our interests have focused on regulation of gene expression. Also our projects have been extended toward effects of environmental endocrine disruptors on the molluscan endocrine system.

Laboratory of Plant Science

The main subject: Basic and applied molecular physiology in microalgae and cyanobacteria.

  • Responses to the environmental factors such as light, CO2 and arsenate.
  • Evolution of algal photosynthesis on glucan synthesis.
  • Contribution of acidic lipids on the function of proteins in thylakoid membranes.
  • Calcification of Coccolithophorid.

Laboratory of Bioenergy Science and Technology

Our laboratory studies microorganisms and microbial communities that are useful in bioenergy generation, pollutant degradation, and environmental protection. Current research topics include:

  • Microbial fuel cells
  • Anaerobic digestion and methanogenesis
  • Wastewater treatment
  • Microbial electrosynthesis of value-added chemicals

Laboratory of Applied Ecology

Our laboratory studies respiration and photosynthesis in terrestrial plants. Current topics are:

  • Ecophysiology of plant respiration in special reference to responses of the mitochondrial respiratory chain to environmental changes
  • Interaction between photosynthesis and respiration in illuminated leaves
  • Physiological mechanisms of understory plants in deciduous forests

Radioisotope Laboratory

We are focusing on extremophiles, including thermophiles and radioresistant microorganisms, which are of biotechnological interest. Thermophilic phages are also our research targets for development of genetic handling system.

Department of Medical Science

Our department studies basic medicine such as cancer, neuroscience, immunology, circulation research, and regenerative medicine. We aim to develop drugs and diagnostic agents based on pathogenic mechanism of diverse diseases.

Laboratory of Genome and Biosignals

We are focusing on the role of phosphoinositide metabolism in cell growth and differentiation.

  • Analysis of physiological functions of phospholipase C in skin homeostasis by using gene-deficient mice
  • Invasion and migration mechanism of cancer cells mediated by phosphoinositide metabolism and cell adhesion molecules
  • Development of new drugs targeting cancer and skin diseases

Laboratory of Molecular Biochemistry

  • Role of mitochondrial ubiquitin ligase MITOL in mitochondrial dynamics and disease
  • Inflammation-induced carcinogenic mechanism via epigenetic change
  • Molecular mechanism of psychiatric disorders
  • Gene therapy using CRAG gene for neurodegenerative disease

Laboratory of Molecular Cell Biology

Newly synthesized secretory/membrane proteins are transported to their target organelles via transport vesicles. This transport system, named vesicular transport, is required cell survival, division, and differentiation. The goal of our laboratory is to understand the molecular mechanisms of membrane fusion and organelle organization.

Laboratory of Cardiovascular Medicine

We emerge to open up new therapeutic windows against cardiovascular diseases by peptide sciences.

  • Modulatory effects of novel peptide hormones on atherogenesis.
  • Biomarkers and therapeutic targets for atherosclerotic cardiovascular diseases.
  • Molecular mechanisms of angiogenesis regulated by TGF-β in vivo.
  • Role of TGF-β signaling in tumor metastases under their microenvironment.

Laboratory of Oncology

Our laboratory is interested in the molecular mechanisms of hematological malignancies, including acute myeloid leukemia and myelodysplastic syndromes (MDS), especially with a specific focus on the role of RUNX1 mutations in MDS. We utilize the gene analysis of patient samples and mouse models to understand the role of the gene alterations to the pathogenesis of MDS. The goal of our studies is to provide novel therapies to patients with MDS.

Laboratory of Immune Regulation

Macrophages and dendritic cells recognize not only microorganisms from outside of the body,but also dying self-cells to eliminate them by engulfment. This clearance prevents the release of potentially harmful or immunogenic intracellularmaterials from dying cells. Our laboratory is investigating the molecularmechanisms for recognition and phagocytosis of dying cells by phagocytes, andthe pathological relevance of impaired phagocytosis to inflammatory disordersincluding autoimmune diseases.

Laboratory of Cellular Regulation

We are focusing on the studies of regulatory mechanisms of cell cycle progression, especially of DNA replication and mitosis.

  • Biochemical analysis of DNA replication in the presence of DNA damage mainlyby using Xenopus egg extract.
  • Molecular and biochemical analysis of the function of a novel ubiquitin ligase on chromosome stability,separation and cytokinesis.