今や生命科学は情報科学と言っても過言ではありません。コンピュータを駆使した生命情報学は、様々な"生命ビッグデータ"を統合し、それらを多面的に解析することで新しい知見を得る学問です。病気の原因究明や新たな治療薬の開発などその応用範囲は無限大です。皆さんも一緒に最先端のデータサイエンス研究をしてみませんか。
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Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai FEBS open bio 12(1) 285-294 2022年1月
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Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins. Atsushi Hijikata, Clara Shionyu, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Tsuyoshi Shirai Biophysics and physicobiology 18 226-240 2021年
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Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation Hiroshi Nihira, Kazushi Izawa, Moeko Ito, Hiroaki Umebayashi, Tsubasa Okano, Shunsuke Kajikawa, Etsuro Nanishi, Dai Keino, Kosaku Murakami, Masahiko Isa-Nishitani, Takeshi Shiba, Yoshitaka Honda, Atsushi Hijikata, Tadateru Yasu, Tomohiro Kubota, Yoshinori Hasegawa, Yusuke Kawashima, Naoko Nakano, Hidetoshi Takada, Shouichi Ohga, Toshio Heike, Junko Takita, Osamu Ohara, Syuji Takei, Makio Takahashi, Hirokazu Kanegane, Tomohiro Morio, Sachiko Iwaki-Egawa, Yoji Sasahara, Ryuta Nishikomori, Takahiro Yasumi Journal of Allergy and Clinical Immunology 2021年
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Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs. Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Tsuyoshi Shirai FEBS letters 594(12) 1960-1973 2020年6月
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Clinical characteristics of adolescent cases with Type A insulin resistance syndrome caused by heterozygous mutations in the β-subunit of the insulin receptor (INSR) gene. Takasawa K, Tsuji-Hosokawa A, Takishima S, Wada Y, Nagasaki K, Dateki S, Numakura C, Hijikata A, Shirai T, Kashimada K, Morio T Journal of diabetes 11(1) 46-54 2019年1月
